Reaction: MTMR14, MTMR3 dephosphorylate PI3P
- in pathway: Macroautophagy
MTMR14 (Jumpy) and MTMR3 are PI3P phosphatases that negatively regulate autophagosome formation by dephosphorylating PI3P on phagophores and autophagosomes (Vergne et al. 2009, Taguchi-Atarashi et al. 2010, Vergne & Deretic 2010).
Reaction - small molecule participants:
PI [endoplasmic reticulum membrane]
PI3P [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-5679206
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Reaction input - small molecules:
phosphatidylinositol 3-phosphate
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol(1-)
Reactome.org link: R-HSA-5679206