Reaction: ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer
- in pathway: HDL assembly
Palmitoylation of ATP-binding cassette sub-family A member 1 (ABCA1) at Cys 3, 23, 1110 and 1111 is essential for its proper trafficking from the ER membrane to the plasma membrane where it is essential for the transport of lipids. The probable palmitoyltransferase ZDHHC8 mediates the palmitoylation of ABCA1 (Singaraja et al. 2009).
Reaction - small molecule participants:
CoA-SH [cytosol]
PALM-CoA [cytosol]
Reactome.org reaction link: R-HSA-5682084
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Reaction input - small molecules:
palmitoyl-CoA(4-)
Reaction output - small molecules:
coenzyme A(4-)
Reactome.org link: R-HSA-5682084