Reaction: PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer
- in pathway: HDL assembly
ATP-binding cassette sub-family A member 1 (ABCA1) is a key mediator of cholesterol and phospholipid efflux to apolipoprotein particles. This efflux activity is regulated by protein kinase A (PKA) site-specific phosphorylation of ABCA1 at Ser-1042 and Ser-2054, located in the nucleotide binding domains of ABCA1 (See et al. 2002).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5682101
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5682101