Reaction: ABCA12 transports lipids from cytosol to extracellular region
- in pathway: ABC transporters in lipid homeostasis
ATP-binding cassette sub-family A member 12 (ABCA12) is thought to function as an epidermal keratinocyte lipid transporter. Lipids such as glucosylceramides and gangliosides form extracellular lipid layers in the stratum corneum of the epidermis, essential for skin barrier function (Akiyama et al. 2005). Mutations in ABCA12 can cause autosomal recessive congenital ichthyoses (ARCI).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
lipids [extracellular region]
lipids [cytosol]
H2O [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5682285
======
Reaction input - small molecules:
lipid
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
lipid
Reactome.org link: R-HSA-5682285