Reaction: LC3 de-lipidation by ATG4
- in pathway: Macroautophagy
LC3:PE can be cleaved by ATG4 to release free LC3 (Kirisako et al. 2000, Kabeya et al. 2004, Kumanomidou et al. 2006, Satoo et al. 2009). ATG4 activity can be regulated by reactive oxygen species (ROS) (Scherz-Shouval et al. 2007) possibily to control release of LC3 from closed autophagosomes.
Reaction - small molecule participants:
PE [phagophore assembly site membrane]
Reactome.org reaction link: R-HSA-5682377
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Reaction input - small molecules:
Reaction output - small molecules:
phosphatidylethanolamine zwitterion
Reactome.org link: R-HSA-5682377