Reaction: p-T68-CHEK2 autophosphorylates
- in pathway: G2/M DNA damage checkpoint
Upon dimerization, p-T68-CHEK2 protomers trans-autophosphorylate on serine residue S379 (Lovly et al. 2008) and threonine residues T383 and T387 (Lee et al. 2001). Autophosphorylation leads to dissociation of CHEK2 dimers into active CHEK2 monomers (Cai et al. 2009).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5683792
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Reaction input - small molecules:
ATP(4-)
ATP(4-)
Reaction output - small molecules:
ADP(3-)
ADP(3-)
Reactome.org link: R-HSA-5683792