Reaction: ULK1 is dephosphorylated
- in pathway: Macroautophagy
Under starvation conditions ULK1 undergoes dephosphorylation, particularly at serine-639 and serine-758 (Shang et al. 2011). The S757 unphosphorylated ULK1 is able to associate with, and be activated by, AMPK (Egan et al. 2011). The protein phosphatase(s) involved in ULK1 dephosphorylation are currently unknown (Wong et al. 2013).
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-5683925
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-5683925