Reaction: CDK2 phosphorylates RBBP8
- in pathway: Processing of DNA double-strand break ends
CDK2, in complex with cyclin A (CCNA), phosphorylates RBBP8 (CtIP) on serine residue S327 and threonine residue T847. Residue T847 is conserved in the yeast ortholog of CtIP, Sae2, and phosphorylation of T847 increases CtIP activity in DNA end resection. Serine S327 phosphorylation enables CtIP to bind BRCA1 (Buis et al. 2012).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5684096
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5684096