Reaction: ATM phosphorylates RBBP8
- in pathway: Processing of DNA double-strand break ends
CDK2-mediated phosphorylation of RBBP8 (CtIP) triggers ATM-mediated phosphorylation of RBBP8 on several ATM consensus SQ/TQ sites. The ATM phosphorylation site at threonine residue T859 of RBBP8 is evolutionarily conserved and seems to be particularly important for the RBBP8-promoted resection of DNA double-strand break (DSB) ends (Wang et al. 2013).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5684140
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5684140