Reaction: NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
- in pathway: Surfactant metabolism
In the multivesicular body, surfactant precursor protein pro-SFTPB is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1992). The resultant mature peptide SFTPB (chain 201-279) forms a dimeric, disulfide-linked protein (Johansson et al. 1992) and is trafficked to lamellar bodies.
Reaction - small molecule participants:
H2O [multivesicular body lumen]
Reactome.org reaction link: R-HSA-5684864
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5684864