Reaction: NAPSA, CTSH, PGA3-5 cleave pro-SFTPC
- in pathway: Surfactant metabolism
In the multivesicular body, surfactant precursor protein pro-SFTPC is most likely proteolytically cleaved by napsin-A (NAPSA), cathepsin-H (CTSH) and pepsinogens 3-5 (PGA3-5) (Chuman et al. 1999, Fuchs & Gassen 1989, Athauda et al. 1989, Johansson et al. 1988). The resultant mature peptide SFTPC (chain 24-58) is trafficked to lamellar bodies.
Reaction - small molecule participants:
H2O [multivesicular body lumen]
Reactome.org reaction link: R-HSA-5685902
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5685902