Reaction: Activated ATM phosphorylates ABL1
- in pathway: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
ATM, activated in response to DNA damage in the form of double-strand breaks, phosphorylates ABL1 (c-ABL) on serine residue S456, resulting in the activation of kinase activity of ABL1 (Baskaran et al. 1997).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5686578
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5686578