Reaction: ABL1 phosphorylates RAD52
- in pathway: HDR through Single Strand Annealing (SSA)
ABL1 (c-ABL), activated by ATM-mediated phosphorylation in response to DNA double-strand breaks (DSBs), phosphorylates RAD52 on tyrosine residue Y104, thus increasing the affinity of RAD52 heptamer for ssDNA and enhancing the efficiency of RAD52-mediated single strand annealing (SSA) (Honda et al. 2011).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5686587
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5686587