Reaction: PKA phosphorylates MAPKAPK5
- in pathway: MAPK6/MAPK4 signaling
MAPKAPK5 is phosphorylated at serine 115 by the catalytic subunit of PKA, which translocates into the nucleus in response to elevated cellular cAMP levels. Phosphorylation at serine 115 promotes the cytoplasmic relocalization of MAPKAPK5 and is required for HSBP1-dependent rearrangements of F-actin in response to PKA (Gerits et al, 2007; Kostenko et al, 2011a; Kostenko et al, 2009; reviewed in Kostenko et al, 2011b)
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5687088
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5687088