Reaction: p-T182 MAPKAPK5 phosphorylates FOXO3
- in pathway: MAPK6/MAPK4 signaling
Activated MAPKAPK5 phosphorylates FOXO3 at serine 215, promoting its activation and translocation to the nucleus. In the nucleus, FOXO3 promotes the expression of miR-34B and C, which in turn represses translation of MYC RNA (Kress et al, 2011; reviewed in Myant and Sansom, 2011; Kostenko et al, 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5687101
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5687101