Meta-Biol

• Pathways

HSBP1, also known as HSP27, is small actin-binding protein with roles in cytoskeletal regulation as well as other processes. HSBP1 is a substrate for MAPKAPK5 both in vitro and in vivo, and phosphorylation of serine residues stimulates forskolin-induced F-actin rearrangements (Sun et al, 2007; Tak et al, 2007; Gerits et al, 2007; New et al, 1998; Seternes et al, 2004; Kostenko et al, 2009a; Kostenko et al, 2009b; Kostenko et al, 2011a; reviewed in Kostenko et al, 2011b; Kostenko et al, 2012). There are divergent reports about the physiological relevance of HSBP1 phosphorylation on actin polymeriztion and cell motility (Lavoie et al, 1995; Lamalice et al, 2007; Katsogiannou et al, 2014; Rousseau et al, 2000; Doshi et al, 2010; Stohr et al, 2012). Actin cytoskeletal rearrangements through the MAPK4 pathway are controlled in part by the IGF2BP1-mediated downregulation of MAPK4 translation which abrogates MAPKAPK5 activity and HSBP1 phosphorylation (Stohr et al, 2012).