Reaction: PRKDC phosphorylates DCLRE1C at DNA DSBs
- in pathway: Nonhomologous End-Joining (NHEJ)
PRKDC (DNA-PKcs) phosphorylates DCLRE1C (ARTEMIS) at least on serine residue S516, and this phosphorylation is necessary for the activation of DCLRE1C endonucleolytic activity (Ma et al. 2002, Ma et al. 2005, Soubeyrand et al. 2006) as it relieves an autoinhibitory conformation of DCLRE1C (Niewolik et al. 2006).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5687183
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5687183