Reaction: MRN and RBBP8 resect DNA DSBs in MMEJ
- in pathway: HDR through MMEJ (alt-NHEJ)
The complex of MRN (MRE11A:RAD50:NBN) and RBBP8 (CtIP) performs a limited resection of DNA double strand breaks (DSBs) in the process of microhomology-mediated end joining (MMEJ) (Yun et al. 2009). ATM activation inhibits MMEJ-related resection of DNA DSBs by MRN, possibly through MRN phosphorylation (Rahal et al. 2010).
Reaction - small molecule participants:
dNTP [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5687464
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Reaction input - small molecules:
water
Reaction output - small molecules:
2'-deoxyribonucleoside triphosphate
Reactome.org link: R-HSA-5687464