Reaction: SIRT4 transfers ADPRib to GLUD
- in pathway: Transcriptional activation of mitochondrial biogenesis
Sirtuin 4 (SIRT4) is a mitochondrial ADP-ribosyltransferase and deacetylase. It uses NAD+ to ADP-ribosylate glutamate dehydrogenase (GLUD), reducing its enzyme activity by at least 50%, leading to reduced insulin secretion in pancreatic beta cells (Haigis et al. 2006, Ahuja et al. 2007).
Reaction - small molecule participants:
NAM [mitochondrial matrix]
NAD+ [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5688276
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
nicotinamide
Reactome.org link: R-HSA-5688276