Reaction: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2
- in pathway: Transcriptional activation of mitochondrial biogenesis
Sirtuin 3 (SIRT3) is the most extensively studied of the mitochondrial sirtuins. It deacetylates and thereby activates Acetyl-CoA synthetase 2 (ACCS2), Glutamate dehydrogenase (GLUD), Isocitrate dehydrogenase 2 (IDH2) and Superoxide dismutase 2 (SOD2) (Schwer et al. 2006, Lombard et al. 2007, Schlicker et al. 2008, Tao et al. 2010).
Reaction - small molecule participants:
2'-O-acetyl-ADP-ribose [mitochondrial matrix]
NAM [mitochondrial matrix]
NAD+ [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5688289
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Reaction input - small molecules:
NAD(1-)
Reaction output - small molecules:
2''-O-acetyl-ADP-D-ribose
nicotinamide
Reactome.org link: R-HSA-5688289