Reaction: USP3,SAGA deubiquitinate Histone H2A,H2B
- in pathway: Ub-specific processing proteases
USP3 dynamically associates with chromatin and deubiquitinates H2A and H2B in vivo. The ZnF-UBP domain of USP3 mediates the H2A-USP3 interaction (Nicassio et al. 2007). USP22, a component of the hSAGA transcriptional coactivator complex, is able to deubiquitinate Histone H2A and H2B (Zhang et al. 2008, Zhao et al. 2008).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5690080
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690080