Reaction: USP5 cleaves polyubiquitin
- in pathway: Ub-specific processing proteases
USP5 (Isopeptidease T) cleaves linear and branched polyubiquitin (polyUb) with a preference for branched polymers (Wilkonson et al. 1995). It is Involved in the disassembly of unattached lysine-48-linked (K48) polyUb. It also binds linear and K63-linked polyUb with a lower affinity (Dayal et al. 2009).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5690152
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690152