Reaction: USP21 deubiquitinates RIPK1,DDX58
- in pathway: Ub-specific processing proteases
USP21 is not required for normal development (Pannu et al. 2015) but is essential in innate and adaptive immune responses (Tao et al. 2014). It negatively regulates NFkB signaling by deubiquitinating Receptor-interacting protein 1 (RIPK1) (Xu et al. 2010) and DDX58 (RIG-I), thereby down-regulating antiviral responses independently of the A20 ubiquitin-editing complex (Fan et al. 2014).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5690159
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690159