Reaction: USP8 deubiquitinates RNF128
- in pathway: Ub-specific processing proteases
The ubiquitin E3 ligase RNF128 (GRAIL) is regulated by auto-K48-linked ubiquitination, which leads to its proteasomal degradation. RNF128 is bound but not deubiquitinated by OTUB1. USP8 binds the RNF128:OTUB1 complex to remove the ubiquitin attached to GRAIL (Soares et al. 2004, Whiting et al. 2011).
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5690196
======
Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690196