Reaction: p-T182-MAPKAPK5 phoshphorylates DNAJB1
- in pathway: MAPK6/MAPK4 signaling
Activated MAPKAPK5 phosphorylates HSP40/DNAJB1 at serines 149, 151 and 171, promoting the ATP hydrolysis activity of the HSP40/HSP70 complex and enhancing the repression of heat shock factor 1 (HSF1) driven transcription by HSP40/DNAJB1 (Kostenko et al, 2014).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5690250
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5690250