Reaction: Histone H2A is dubiquitinated by the PR-DUB complex
- in pathway: UCH proteinases
BAP1 is the catalytic component of the PR-DUB complex, which deubiquitinates Lysine-120 monoubiquitinated Histone H2A (H2AK119ub1) (Scheuermann et al. 2010). The PR-DUB complex consists of BAP1, ASXL1/2, KDM1B, FOXK1/2, HCFC1 and MBD5/6 (Yu et al. 2010, Dey et al. 2012, Baymaz et al. 2014).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5690790
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690790