Reaction: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1
- in pathway: Ovarian tumor domain proteases
TNFAIP3 (A20) removes lysine-63 (K63)-linked ubiquitin chains from Receptor interacting protein (RIPK1), an essential mediator of the proximal TNF receptor 1 (TNFR1) signalling complex. The carboxy-terminal domain of A20 then functions as a ubiquitin ligase, polyubiquitinating RIPK1 with K48-linked ubiquitin chains, thereby targeting RIPK1 for proteasomal degradation (Wertz et al. 2004) which leads to termination of TNF- or LPS-mediated activation of NF-kappa-B.
Reaction - small molecule participants:
H2O [cytosol]
Reactome.org reaction link: R-HSA-5690856
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5690856