Reaction: ACO1:4Fe-4S isomerises CIT to ISCIT
- in pathway: Iron uptake and transport
Cytoplasmic aconitate hydratase (ACO1, iron regulatory protein 1, IRP1) functions either as an RNA binding protein that regulates the uptake, sequestration, and utilisation of iron or an enzyme that isomerises citrate to isocitrate, depending on changes in cellular iron levels. Under iron-replete conditions, ACO1 binds the cofactor 4Fe-4S cluster and acts as an aconitase, isomerising citrate (CIT) to isocitrate (ISCIT) (Kaptain et al. 1991, Philpott et al. 1994, Dupuy et al. 2006).
Reaction - small molecule participants:
ISCIT [cytosol]
CIT [cytosol]
Reactome.org reaction link: R-HSA-5690911
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Reaction input - small molecules:
citric acid
Reaction output - small molecules:
D-threo-isocitrate(3-)
Reactome.org link: R-HSA-5690911