Reaction: FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)
- in pathway: Iron uptake and transport
Mitochondrial ferritin (FTMT) is specifically taken up by the mitochondria and processed to a mature protein that assembles into functional ferritin shells. It is a homooligomer of 24 subunits, is roughly spherical and contains a central cavity into which the mineral iron core is deposited. FTMT possesses ferroxidase activity. Iron is taken up in the ferrous form (Fe2+) and deposited as ferric hydroxide (Fe(3+)O(OH)) after oxidation. FTMT may play an important role in the regulation of iron homeostasis in the mitochondrion (Levi et al. 2001, Langlois d'Estaintot et al. 2004).
Reaction - small molecule participants:
Fe(3+)O(OH) [mitochondrial matrix]
O2 [mitochondrial matrix]
Fe2+ [mitochondrial matrix]
H+ [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5691107
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Reaction input - small molecules:
dioxygen
iron(2+)
hydron
Reaction output - small molecules:
iron(III) oxide-hydroxide(1-)
Reactome.org link: R-HSA-5691107