Reaction: MYSM1 deubiquitinates Histone H2A
- in pathway: Metalloprotease DUBs
MYSM1 is required for full activation of several transcriptional events, including androgen receptor (AR)-regulated target genes in prostate cancer cells. It is part of a regulatory protein complex with the histone acetyltransferase EP300 (p300) and KAT2B (CBP-associated factor (p/CAF)), regulating transcriptional initiation and elongaion by coordinating histone acetylation, H2A deubiquitination and linker histone dissociation. MYSM1 preferentially deubiquitinates H2A in hyperacetylated nucleosomes (Zhu et al. 2007).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5691381
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5691381