Reaction: BRCA1-A complex deubiquitinates K63polyUb-histone H2A
- in pathway: Metalloprotease DUBs
BRCC3 (BRCC36) as part of the BRCA1-A complex, antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks (Shao et al. 2009), specifically removing Lysine-63-linked polyubiquitin on histone H2A and H2AX. K63-linked polyubiquitination of H2A is induced by DNA damage and is required for the DNA repair response (Cao & Yan, 2012).
Reaction - small molecule participants:
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-5691411
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-5691411