Reaction: ADH5 oxidises S-HMGSH to S-FGSH
- in pathway: Ethanol oxidation
Alcohol dehydrogenase class-3 (ADH5) is a cytosolic dimeric enzyme that binds 2 Zn2+ per subunit. It is very ineffective in oxidising ethanol, but it readily catalyses the oxidation of S-(hydroxymethyl) glutathione (S-HMGSH) to S-formylglutathione (S-FGSH) (Kaiser et al. 1988, Julia et al. 1988) as well as the oxidation of long-chain primary alcohols (not shown here).
Reaction - small molecule participants:
S-FGSH [cytosol]
H+ [cytosol]
NADH [cytosol]
S-HMGSH [cytosol]
NAD+ [cytosol]
Reactome.org reaction link: R-HSA-5692237
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Reaction input - small molecules:
S-(hydroxymethyl)glutathione
NAD(1-)
Reaction output - small molecules:
S-formylglutathione
hydron
NADH(2-)
Reactome.org link: R-HSA-5692237