Reaction: ATP13A2 transports cations from cytosol to lysosomal lumen
- in pathway: Ion transport by P-type ATPases
The probable cation-transporting ATPase 13A2 (ATP13A2) is thought to play a role in intracellular cation homeostasis and the maintenance of neuronal integrity (Ramonet et al. 2012). Defects in ATP13A2 can cause Kufor-Rakeb syndrome (KRS; MIM:606693), a juvenile-onset Levodopa-responsive parkinsonism (Lai et al. 2012).
Reaction - small molecule participants:
Pi [cytosol]
ADP [cytosol]
cation [lysosomal lumen]
H2O [cytosol]
ATP [cytosol]
cation [cytosol]
Reactome.org reaction link: R-HSA-5692480
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Reaction input - small molecules:
water
ATP(4-)
cation
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
cation
Reactome.org link: R-HSA-5692480