Reaction: SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs
- in pathway: MAPK6/MAPK4 signaling
MAPK6 and MAPKAPK5 directly phosphorylate the septin regulating proteins CDC42EP2, 3 and 5 (also known as BORG1, 2 and 3 for Binders of Rho GTPases) in vitro. BORG/CDC42EP proteins interact with septins through the septin GTPase domain and inhibit filament formation. This effect of the BORG proteins on septin filamentation is itself inhibited by CDC42 (Jouberty et al, 2001; reviewed in Spiliotis and Nelson, 2006). The interaction between SEPT7 and the CDC42EP proteins may facilitate their recruitment to the ternary MAPK6:MAPKAPK5:SEPT7 complex for phosphorylation, although the significance of this phosphorylation is not yet clear (Brand et al, 2012).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-5692775
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5692775