Reaction: p-T182 MAPKAPK5 phosphorylates FOXO1
- in pathway: MAPK6/MAPK4 signaling
MAPKAPK5 phosphorylates FOXO1 at S218 (corresponds to S215 in mouse Foxo1). This phosphorylation is essential for the FOXO1-dependent activation of RAG gene transcription during B-cell development and promotes the direct binding of FOXO1 to the RAG gene promoter (Chow et al, 2013).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5692779
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5692779