Reaction: DNA-PKcs autophosphorylates
- in pathway: Nonhomologous End-Joining (NHEJ)
Autophosphorylation of DNA-PKcs (PRKDC) is required for NHEJ in vivo, especially for endonucleolytic processing of DNA double strand break ends, which makes them suitable for ligation (Chan et al, 2002; Ding et al, 2003). In vivo, PRKDC autophosphorylates at threonine residues T2609, T2638 and T2647, and serine residue S2612 (Douglas et al. 2002).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5693575
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-5693575