Reaction: D-loop dissociation and strand annealing
Following repair synthesis, the extended D-loop strands may disassociate from their sister chromatid complements and reanneal with their original complementary strands. A DNA helicase RTEL1 disrupts preformed D-loops and promotes synthesis-dependent strand annealing, yielding non-crossover products and preventing excessive recombination between mitotic sister chromatids (Barber et al. 2008, Uringa et al. 2012).
Reaction - small molecule participants:
Pi [nucleoplasm]
ADP [nucleoplasm]
H2O [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-5693589
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Reaction input - small molecules:
water
ATP(4-)
Reaction output - small molecules:
hydrogenphosphate
ADP(3-)
Reactome.org link: R-HSA-5693589