Reaction: DUOX1,2 reduce O2 to H2O2
- in pathway: Thyroxine biosynthesis
Dual oxidases 1 and 2 (DUOX1, 2) mediates the generation of hydrogen peroxide (H2O2) which is required for the activity of thyroid peroxidase for thyroid hormone formation and lactoperoxidase (Edens et al. 2001, Ameziane-El-Hassani et al. 2005).
Reaction - small molecule participants:
NADP+ [extracellular region]
H2O2 [extracellular region]
H+ [extracellular region]
NADPH [extracellular region]
O2 [extracellular region]
Reactome.org reaction link: R-HSA-5693681
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Reaction input - small molecules:
hydron
NADPH
dioxygen
Reaction output - small molecules:
NADP(+)
hydrogen peroxide
Reactome.org link: R-HSA-5693681