Reaction: ESD dimer hydrolyses S-FGSH to GSH
- in pathway: Glutathione conjugation
S-formylglutathione hydrolase (ESD, esterase D) is a homodimeric enzyme in the ER lumen of red blood cells that can hydrolyse S-formylglutathione (S-FGSH) to glutathione (GSH) and formate (Hopkinson et al. 1973, Eiberg & Mohr 1986). It is also able to hydrolyse 4-methylumbelliferyl acetate (not shown here).
Reaction - small molecule participants:
GSH [endoplasmic reticulum lumen]
formate [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
S-FGSH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-5693724
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Reaction input - small molecules:
water
S-formylglutathione
Reaction output - small molecules:
glutathione
formate
Reactome.org link: R-HSA-5693724