Reaction: FA2H hydroxylates CERA
- in pathway: Sphingolipid de novo biosynthesis
In mammals, 2-hydroxysphingolipids are abundant in the brain as components of the major myelin lipids galactosylceramides and sulfatides. 2-hydroxylation of sphingolipids can occur during de novo ceramide synthesis and is catalysed by fatty acid 2-hydroxylase (FA2H), an ER membrane-associated enzyme (Alderson et al. 2004, Uchida et al. 2007).
Reaction - small molecule participants:
2HCERA [endoplasmic reticulum membrane]
H2O [cytosol]
O2 [cytosol]
CERA [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-5693761
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Reaction input - small molecules:
dioxygen
N-acylsphingoid
Reaction output - small molecules:
N-(2-hydroxyacyl)sphingoid
water
Reactome.org link: R-HSA-5693761