Reaction: NAALADases hydrolyse NAAG
- in pathway: Aspartate and asparagine metabolism
Excessive glutamate has been implicated in neurodegenerative disorders and stroke. One source of glutamate is from the hydrolysis of N-acetylaspartylglutamate (NAAG), a neurotransmitter found in the brain. NAAG can he hydrolysed by glutamate carboxypeptidase 2 (FOLH1), a membrane-bound, homodimeric enzyme which possesses both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity (Mesters et al. 2006). Inhibition of FOLH1 could have neuroprotective effects (Wozniak et al. 2012). Other dipeptidases able to hydrolyse NAAG are N-acetylated-alpha-linked acidic dipeptidase 2 (NAALAD2) (Pangalos et al. 1999, Hlouchova et al. 2009) and putative N-acetylated-alpha-linked acidic dipeptidase (FOLH1B) (O'Keefe et al. 2004).
Reaction - small molecule participants:
L-Glu [cytosol]
NAASP [cytosol]
NAAG [cytosol]
Reactome.org reaction link: R-HSA-5693783
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Reaction input - small molecules:
Ac-Asp-Glu(3-)
Reaction output - small molecules:
L-glutamate(1-)
N-acetyl-L-aspartate(2-)
Reactome.org link: R-HSA-5693783