Reaction: FUT3 transfers L-fucose to Gal1,3GlcNAc
Human galactoside 3(4)-L-fucosyltransferase (FUT3) may be involved in Lewis blood group (Le) determination. Le+ individuals have an active enzyme while Le- individuals have an inactive enzyme. FUT3 catalyses alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Le blood groups. The 1,3-galactosyl derivative is shown here (Cameron et al. 1995).
Reaction - small molecule participants:
Gal1,3Fuc1,4GlcNAc group [Golgi lumen]
GDP [Golgi lumen]
Gal1,3GlcNAc group [Golgi lumen]
GDP-Fuc [Golgi lumen]
Reactome.org reaction link: R-HSA-5693925
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Reaction input - small molecules:
beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl group
GDP-L-fucose
Reaction output - small molecules:
beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-D-glucosaminyl group
GDP(3-)
Reactome.org link: R-HSA-5693925