Reaction: AMT transfers NH2CH2 from GCSH:SAMDLL to THF
- in pathway: Glycine degradation
The major degradative pathway for the amino acid glycine is via the glycine cleavage system. In the second reaction in this system, the decarboxylated moiety from glycine decarboxylation attached to H protein (GCSH:SAMDLL) is further degraded by mitochondrial aminomethyltransferase (AMT, GCST, T protein) to ammonia (NH3) and GCSH with reduced lipoate. Tetrahydrofolate (THF) is required for this reaction and accepts the methyl group to form 5,10MTHF (Fujiwara et al. 1984).
Reaction - small molecule participants:
NH3 [mitochondrial matrix]
5,10-methylene-THF [mitochondrial matrix]
THF [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5693977
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Reaction input - small molecules:
(6S)-5,6,7,8-tetrahydrofolic acid
Reaction output - small molecules:
ammonia
5,10-methylenetetrahydrofolate(2-)
Reactome.org link: R-HSA-5693977