Reaction: GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
- in pathway: Pyruvate metabolism
Lactoylglutathione lyase (GLO1) catalyses the transformation of methylglyoxal (MGXL) and glutathione (GSH) to (R)-S-lactoylglutathione ((R)-S-LGSH), an intermediate in pyruvate metabolism. MGXL is a reactive 2-oxoaldehyde byproduct of normal metabolism that is a carcinogen and a mutagen (Ridderstrom et al. 1998). This is the first step in the glyoxalase system, a critical two-step detoxification system for MGXL.
Reaction - small molecule participants:
(R)-S-LGSH [cytosol]
MGXL [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-5694071
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Reaction input - small molecules:
methylglyoxal
glutathionate(1-)
Reaction output - small molecules:
(R)-S-lactoylglutathione
Reactome.org link: R-HSA-5694071