Reaction: EPHX1 hydrates BaP4,5O to BaP4,5-DHD
- in pathway: Phase I - Functionalization of compounds
Microsomal epoxide hydrolase 1 (EPHX1) is involved in the metabolism of many potentially carcinogenic and/or genotoxic epoxides, such as those derived from the oxidation of polyaromatic hydrocarbons. It catalyses the hydration of arene and aliphatic epoxides to less reactive and more water-soluble dihydrodiols. An example substrate is epoxide benzo(a)pyrene 4,5-oxide (BaP4,5O), hydrated to benzo(a)pyrene 4,5-dihydrodiol (BaP4,5DHD) (Hosagrahara et al. 2004, Fretland & Omiecinski 2000).
Reaction - small molecule participants:
BaP4,5-DHD [cytosol]
H2O [cytosol]
BaP4,5O [cytosol]
Reactome.org reaction link: R-HSA-5694077
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Reaction input - small molecules:
water
Benzo[a]pyrene-4,5-oxide
Reaction output - small molecules:
Benzo[a]pyrene-cis-4,5-dihydrodiol
Reactome.org link: R-HSA-5694077