Reaction: NT5C3B hydrolyses 7MGP to 7MG
- in pathway: mRNA decay by 3' to 5' exoribonuclease
Cytosolic 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) specifically hydrolyses N(7)-methylguanosine monophosphate (7MGMP) to 7-methylguanosine (7MG) and inorganic phosphate (Pi). 7MGP is a modified nucleotide byproduct of mRNA turnover and requires degradation as its incorporation into nucleic acids is undesirable (Buschmann et al. 2013).
Reaction - small molecule participants:
Pi [cytosol]
7MG [cytosol]
H2O [cytosol]
7MGMP [cytosol]
Reactome.org reaction link: R-HSA-5694126
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Reaction input - small molecules:
water
7-methylguanosine 5'-phosphate(1+)
Reaction output - small molecules:
hydrogenphosphate
7-methylguanosine
Reactome.org link: R-HSA-5694126