Reaction: PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser
- in pathway: Metabolism of folate and pterines
Mitochondrial serine hydroxymethyltransferase (SHMT2) contributes to the de novo mitochondrial thymidylate biosynthesis pathway which is essential for mitochondrial DNA (mtDNA) integrity. It is associated with the inner mitochondrial membrane and is functional as a homotetramer. SHMT2 transfers a hydroxymethyl group from 5,10-methylenetetrahydrofolate (5,10MTHF) to glycine (Gly), forming tetrahydrofolate (THF) and L-serine (L-Ser) (Anderson et al. 2011).
Reaction - small molecule participants:
THF [mitochondrial matrix]
L-Ser [mitochondrial matrix]
Gly [mitochondrial matrix]
5,10-methylene-THF [mitochondrial matrix]
H2O [mitochondrial matrix]
Reactome.org reaction link: R-HSA-5694137
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Reaction input - small molecules:
glycine zwitterion
5,10-methylenetetrahydrofolate(2-)
water
Reaction output - small molecules:
(6S)-5,6,7,8-tetrahydrofolic acid
L-serine zwitterion
Reactome.org link: R-HSA-5694137