Meta-Biol

• Pathways

Three members of the serine hydrolase family are involved in the degradation of the endocannabinoid 2-arachidonoylyglycerol (C20:4) (2AG). The major enzymatic route for 2AG inactivation is via hydrolysis, generating arachidonic acid (AA) and glycerol. Two of the serine hydrolases, monoacylglycerol lipases 6 and 12 (ABHD6 and 12), have preference for the 3-acyl isomer of arachidonoylyglycerol (3AG) although they can also hydrolyse 2AG at a lower rate (Navia-Paldanius et al. 2012, Savinainen et al. 2012).