Reaction: ABHD3 hydrolyses LPC(14:0) to 1AGPC
- in pathway: Synthesis of PC
Phospholipase ABHD3 selectively cleaves medium-chain and oxidatively-truncated phospholipids, having much higher phospholipase activity toward C14-containing phosphatidylcholines such as lysophosphatidylcholine (LPC(14:0)) and producing 1-acylglycerophosphocholine (1AGPC) (Long et al. 2011). ABHD3 is ubiquitously expressed with highest expression in brain and small intestine (Lord et al. 2013).
Reaction - small molecule participants:
1AGPC [plasma membrane]
RCOO- [cytosol]
H2O [cytosol]
LPC(14:0) [plasma membrane]
Reactome.org reaction link: R-HSA-5694485
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Reaction input - small molecules:
water
lysophosphatidylcholine 14:0
Reaction output - small molecules:
1-acylglycerophosphocholine(1+)
fatty acid anion
Reactome.org link: R-HSA-5694485