Reaction: Loss of SAR1B GTPase
- in pathway: COPII-mediated vesicle transport
Sar1p-GTP hydrolysis is increased 15-30-fold by Sec23p. Sar1p-GDP is released as a result of this hydrolysis and used in further vesicle sculpting cycles. Sar1p-GTP hydrolysis occurs at two critical points during the cycle, first (as represented here) as a proofreading step, insuring that the cargo is loaded. Later in the cycle Sar1p-GTP hydrolysis triggers the uncoating of the budded vesicle.
Reaction - small molecule participants:
Pi [cytosol]
Reactome.org reaction link: R-HSA-5694527
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Reaction input - small molecules:
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-5694527